The genetic code is the cornerstone of life on earth, the fundamental set of biochemical rules that distinguish living organisms from non-living matter. The quantitative relationships between the DNA bases in the codons permit the description of the genetic code as a cube inserted in the three dimensional space.
The genetic code can be represented as Boolean lattice as well, which is in directed correspondence with a graph called Hasse diagram. The role of the hydrophobicity in the distribution of codons assigned to each amino acid is reflected on Hasse diagram symmetry.
Methyl-IT R package. A signal detection based approach for methylation analysis. Since the biological signal created within the dynamic methylome environment characteristic of living organisms is not free of background noise, application of signal detection theory is required (get Methyl-IT here).
To know in advance the fixation probability of immune escape epitopes is essential to build successful vaccines. The fixation probabilities of mutational events on viral proteins can be estimated in a thermodynamics framework of the symmetric group of genetic-code cubes (get Computational Document Format (CDF) here)